Eduard de Winter
phd-candidate vascular surgery
Curriculum Vitae
Eduard obtained his medical degree in 2022 after studying medicine at Leiden university. During his clinical work at the department of surgery in the Haaglanden Medical Centre (HMC), the Hague, he also participated in clinical studies on the predictive value of intraoperative blood flow on maturation rates of arteriovenous fistulas (AVFs), and the beneficial effects of preoperative forearm exercises on AVFs. Further exploring his interest in vascular surgery, he started in the group of Dr. M.R. de Vries and Prof. Dr. Quax in the Leiden University Medical Centre (LUMC) in 2023, where he will focus on pre-clinical research involving singe cell RNA sequencing in arteriovenous fistulas in murine models.
Recent publications
Site Selectivity of Peptoids as Azobenzene Scaffold for Molecular Solar Thermal Energy Storage
Site Selectivity of Peptoids as Azobenzene Scaffold for Molecular Solar Thermal Energy Storage
Storing solar energy is a key challenge in modern science. MOlecular Solar Thermal (MOST) systems, in particular those based on azobenzene switches, have received great interest in the last decades. The energy storage properties of azobenzene (t <4 days; ΔH~270 kJ/kg) must be improved for future applications. Herein, we introduce peptoids as programmable supramolecular scaffolds to improve the energy storage properties of azobenzene-based MOST systems. We demonstrate with 3-unit peptoids bearing a single azobenzene chromophore that dynamics of the MOST systems can be tuned depending on the anchoring position of the photochromic unit on the macromolecular backbone. We measured a remarkable increase of the half-life of the metastable form up to 14 days at 20 °C for a specific anchoring site, significantly higher than the isolated azobenzene moiety, thus opening new perspectives for MOST development. We also highlight that liquid chromatography coupled to mass spectrometry does not only enable to monitor the different stereoisomers during the photoisomerization process as traditionally done, but also allows to determine the thermal back-isomerization kinetics.